March 17, 2023

Everything About ᴡᴏᴍʙ Milk Nourishes Human ᴇᴍʙʀʏᴏ During First Weeks Of Pregnancy You Need To Know

Everything About ᴡᴏᴍʙ Milk Nourishes Human ᴇᴍʙʀʏᴏ During First Weeks Of Pregnancy You Need To Know

For the first 11 weeks of pregnancy, before the mother’s nutrient-rich ʙʟᴏᴏᴅ supply is plumbed in, all the materials and energy for building a baby are supplied by secretions from ɢʟᴀɴᴅs in the ᴜᴛᴇʀᴜs lining.  For the first time, ʀᴇsᴇᴀʀᴄʜᴇʀs have worked out in detail how nutrients make their way from these ɢʟᴀɴᴅs into the developing ᴇᴍʙʀʏᴏ. “It’s like a rapidly growing building site,” says John Aplin of the University of Manchester, UK.

During pregnancy, the lining of the ᴜᴛᴇʀᴜs behaves quite differently to normal: the ɢʟᴀɴᴅs start storing large amounts of glucose as glycogen, which is then secreted to nourish the ᴇᴍʙʀʏᴏ during its first 11 weeks.

After this time, the mother’s ʙʟᴏᴏᴅ supply delivered via the ᴜᴍʙɪʟɪᴄᴀʟ ᴄᴏʀᴅ takes over and the “ᴡᴏᴍʙ-milk” secretions dry up. But how the glycogen and other materials for baby-building were transported to the ᴇᴍʙʀʏᴏ and placenta was a mystery until now.

Vital nutrients
To investigate, Aplin and his colleagues examined ᴡᴏᴍʙ, placenta and ᴇᴍʙʀʏᴏnic tissue donated by women who had chosen to ᴛᴇʀᴍɪɴᴀᴛᴇ their pregnancies. The samples came from all stages of early pregnancy, so the ʀᴇsᴇᴀʀᴄʜᴇʀs were able to analyse how they changed over time.

By using a sᴛᴀɪɴɪɴɢ ᴅʏᴇ, they were able to see wherever glycogen was present in the tissues. They found that it was abundant in the recesses of the ᴡᴏᴍʙ lining, where it is broken down into smaller molecules. These molecules then diffuse into a cavity just outside the placenta, known as the intervillous space. From there, they are absorbed into the placenta.

“Once the sugar is there, some is used straight away as energy to help the ᴇᴍʙʀʏᴏ grow, and the rest is reconverted to the storage molecule, glycogen,” says Aplin.

Tʜᴇ ᴛᴇᴀᴍ also tracked the transport of substances called glycoproteins. These are vital for growth because as well as containing sugar fragments, they contain protein that can be broken down into amino acids – the building blocks from which tissue is assembled.

Pʀᴇᴄᴀʀɪᴏᴜs state
Aplin says that in the first crucial weeks, ᴡᴏᴍʙ milk is the ᴇᴍʙʀʏᴏ’s only source of nourishment. This is no ᴀᴄᴄɪᴅᴇɴᴛ: at the beginning of a pregnancy, the placenta is much larger than the growing ᴇᴍʙʀʏᴏ, so the pressure of ᴀʀᴛᴇʀɪᴀʟ ʙʟᴏᴏᴅ would likely dislodge the ᴇᴍʙʀʏᴏ from the wall of the ᴜᴛᴇʀᴜs. Only by 11 weeks or so is it big enough to withstand and accept its mother’s ʙʟᴏᴏᴅ.

Next, Aplin and his colleagues hope to investigate how a mother’s ᴅɪᴇᴛ and other factors, such as sᴍᴏᴋɪɴɢ, affect the build-up of glycogen in the ᴡᴏᴍʙ lining. “It could be that these trigger settings in the ᴇᴍʙʀʏᴏ that affect the ʀɪsᴋ ᴏF ᴏʙᴇsɪᴛʏ ᴏʀ ᴅɪᴀʙᴇᴛᴇs in life,” he says.

“The first few weeks of pregnancy is a critical phase for ᴇᴍʙʀʏᴏnic development,” says Graham Burton of the University of Cambridge, whose team discovered in 2002 that the ᴜᴛᴇʀᴜs lining – not the mother’s ʙʟᴏᴏᴅ – nourishes the ᴇᴍʙʀʏᴏ.

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